Prof. Yoni Haitin

Every cell in our body interacts with its environment. These ever-lasting cellular conversations serve to pass crucial information important for promoting and maintaining numerous processes, which enable the cells to respond to their changing surroundings. Our lab utilizes cutting-edge methods in order to delineate the structural mechanisms underlying the activity and allosteric regulation of two types of enzymes: Ion channels, catalyzing the movement of ions across cell membranes, and prenyltransferases, synthesizing moieties for post-translational protein modification. Importantly, we focus on deciphering their essential roles for cellular proliferation and analyze pathophysiological mechanisms associated with cancerous transformation.