Prof. Roy Alcalay
Research work
The laboratory research focus is genetics and biomarkers in Parkinson's disease and other neurodegenerative disorders. We collect biomarkers and genetically analyze samples of people with Amyotrophic Lateral Sclerosis (ALS), dementia, ataxia and Creutzfeldt-Jakob disease (CJD). We aim to better understand the molecular and cellular mechanisms of neurodegeneration, identify biomarkers, and to assist in delaying or even in preventing these diseases.
Areas of interest & scientific knowledge
Clinical Neuroscience
Neurodevelopment and Neurogenetic Research
Specialization
Selected Publications
- Cook L, Verbrugge J, Schwantes-An TH, Schulze J, Beck JC, Naito A, Hall A, Chan AK, Casaceli CJ, Marder K, Nance M, Schwarzschild MA, Simuni T, Wills AM, Alcalay RN; Parkinson’s Foundation and Parkinson's Study Group (PSG). Providing genetic testing and genetic counseling for Parkinson's disease to the community. Genet Med. 2023 Oct;25(10):100907. https://www.sciencedirect.com/science/article/pii/S1098360023009206?via%3Dihub
- Avisar H, Guardia-Laguarta C, Surface M, Papagiannakis N, Maniati M, Antonellou R, Papadimitriou D, Koros C, Athanassiadou A, Przedborski S, Lerner B, Stefanis L, Area-Gomez E, Alcalay RN. Lipid level alteration in human and cellular models of alpha synuclein mutations. NPJ Parkinsons Dis. 2022 Apr 25;8(1):52. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039073/
- Shani S, Goldstein O, Gana-Weisz M, Bar-Shira A, Thaler A, Gurevich T, Mirelman A, Giladi N, Alcalay RN, Orr-Urtreger A. Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers. Parkinsonism Relat Disord. 2023 Jun;111:105398. PMID: 37116292.
- Surface M, Balwani M, Waters C, Haimovich A, Gan-Or Z, Marder KS, Hsieh T, Song L, Padmanabhan S, Hsieh F, Merchant KM, Alcalay RN. Plasma Glucosylsphingosine in GBA1 Mutation Carriers with and without Parkinson's Disease. Mov Disord. 2022 Feb;37(2):416-421. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840974/
- Shani S, Gana-Weisz M, Bar-Shira A, Thaler A, Gurevich T, Mirelman A, Giladi N, Alcalay RN, Goldstein O, Orr-Urtreger A. MAPT Locus in Parkinson's Disease Patients of Ashkenazi Origin: A Stratified Analysis. Genes (Basel). 2023 Dec 28;15(1):46. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10815687/
