Prof. Yoav Henis
Research work
Our research topics deal with biophysical studies on cancer development mechanisms:
• Mechanism of cell growth inhibition and anti-tumor activity of TGF-b superfamily receptors
• Endocytosis of activin and BMP receptors and its roles in signaling via specific pathways
• Mechanisms of the formation, dynamics and roles of biocondensates, focusing on the TAZ transcription factor
Areas of interest & scientific knowledge
Cellular & Molecular Neuroscience
Imaging Research
Selected Publications
Past 3 years:
- Sharma, S., Ehrlich, M., Zhang, M., Blobe, G. C. and Henis, Y. I. (2024) NRP1 interacts with endoglin and VEGFR2 to modulate VEGF signaling and endothelial cell sprouting. Commun. Biol. 7, 112.
- Chaudhary, R., Goodman, L.S., Wang, S., Asimakopulos, A., Weiskirchen, R., Dooley, S., Ehrlich, M. and Henis, Y. I. (2024) Cholesterol modulates type I/II TGF- receptor complexes and alters the balance between Smad and Akt signaling in hepatocytes. Commun. Biol. 7, 8.
- Wang, S., Link, F., Han, M., Chaudhary, R., Asimakopoulos, A., Liebe, R., Yao, Y., Hammad, S., Dropmann, A., Krizanac, M., Rubie, C., Feiner, L. K., Glanemann, M., Ebert, M. P. A., Weiskirchen, R., Henis, Y. I., Ehrlich, M. and Dooley, S. (2024) The interplay of TGF-1 and cholesterol orchestrating hepatocyte cell fate, EMT, and signals for HSC activation. Cell. Mol. Gastroenterol. Hepatol. 17, 567-587.
- Szilagyi, S. S., Burdzinski, W., Jatzlau, J., Ehrlich, M., Knaus, P. and Henis, Y. I. (2024) The activation of the Fibrodysplasia Ossificans Progressiva-inducing ALK2-R206H mutant depends on the distinct homo-oligomerization patterns of ACVR2B and ACVR2A. Cells 13, 221.
- Chaudhary, R., Weiskirchen, R., Ehrlich, M. and Henis, Y. I. (2025) Dual signaling pathways of TGF- superfamily cytokines in hepatocytes: balancing liver homeostasis and disease progression. Front. Pharmacol. 16, 1580500.
- Akerman, A., Gutman, O., Shapira, K. E., Lewinsohn, E., Henis, Y. I. and Yalovsky, S. (2026) C-terminal S-acylation governs membrane distribution, interaction dynamics and function of a plant Rho GTPase. PLoS One 21, e0348444.
