

Prof. Roy Beck-Barkai
Research work
Nature evolved to have the unbelievable capabilities to produce nanoscale machines with incredible accuracy and functionality. In Beck’s lab, we experimentally study the physical mechanism responsible for these fantastic capabilities. Using X-ray scattering, microscopy, spectroscopy, and other biophysical techniques, we target the nano length-scale biophysics. We further combine advancing theories originating from soft-matter and statistical mechanics physics for the study of various self-assembled systems in and out of thermal equilibrium. Examples include intrinsically disordered proteins, amphiphiles self-assembly, intermediate filaments, and myelin sheaths biophysics.
Areas of interest & scientific knowledge
Cellular & Molecular Neuroscience
Selected Publications
- G. Koren, S. Meir, L. Holschuh, H. DT Mertens, T. Ehm, N. Yahalom, A. Golombek, T. Schwartz, D.I. Svergun, O.A. Saleh, J. Dzubiella, R. Beck, Intramolecular Structural Heterogeneity altered by Long-range Contacts in an Intrinsically Disordered Protein, Proceedings of the National Academy of Sciences of the USA 120 (30) e2220180120 (2023)
- G. Jacoby, M. Segal Asher, T. Ehm, I. Abutbul Ionita, H. Shinar, S. Azoulay-Ginsburg, D. Danino, M. M. Kozlov, R. J. Amir, R. Beck, Order from disorder with intrinsically disordered peptide amphiphiles, Journal of the American Chemical Society 143, 11879-11888 (2021)
- T. Ehm, H. Shinar, S. Meir, A. Sekhon, V. Sethi, I. L. Morgan, G. Rahamim, O. A. Saleh, R. Beck, Intrinsically Disordered Proteins at the Nano-scale, (2021). Nano Futures 5(2), 022501 (2021)
- I. Morgan, R. Avinery, G. Rahamim, R. Beck, O. Saleh, Glassy dynamics and memory effects in an intrinsically disordered protein construct, Physical Review Letters 125, 058001 (2020)
- R. Shaharabani, M. Ram-On, Y. Talmon, R. Beck, Pathological transitions in myelin membranes driven by environmental and multiple sclerosis conditions, Proceedings of the National Academy of Sciences of the USA 44(115), 11156-11161 (2018)
- M. Kornreich, E. Malka Gibor, B. Zuker, A. Laser Azogui, R. Beck, Neurofilaments function as shock absorbers: compression response arising from disordered proteins, Physical Review Letters 117, 148101 (2016). DOI: 10.1103/PhysRevLett.117.148101
- A. Laser-Azogui M. Kornreich, E. Malka-Gibor, R. Beck, Neurofilament assembly and function during neuronal development. Current Opinion in Cell Biology 32, 92-101 (2015)