Dr. Tamara Shiner
Most of our research activity is focused on the study of Dementia with Lewy Bodies (DLB), the second most common cause of neurodegenerative dementia worldwide. A key aim for ours is to further the understanding of the genetic contribution to DLB by characterizing the effect of common genetic factors such as mutations in the GBA gene and APOE polymorphisms on the clinical profile. We also utilize structural imaging with 3T MRI and functional imaging with FDG-PET and EEG in order to better explore the effect of these genetic factors. As part of our work we study healthy first degree family members of patients, in order to try to identify prodromal markers in people who have an increased genetic risk. The key aim is to better characterize and identify patients at prodromal or very early stages of disease with the aim of improving the selection of personalized medical treatments.
Clinical Neuroscience
Cognitive Neuroscience
Imaging Research
- The Effect of GBA Mutations and APOE Polymorphisms on Dementia with Lewy Bodies in Ashkenazi Jews. Shiner T, Mirelman A, Rosenblum Y, Kavé G, Weisz MG, Bar-Shira A, Goldstein O, Thaler A, Gurevich T, Orr-Urtreger A, Giladi N, Bregman N. J Alzheimers Dis. 2021;80(3):1221-1229.
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad2... - Differential changes in visual and auditory event-related oscillations in dementia with Lewy bodies.
Rosenblum Y, Maidan I, Fahoum F, Giladi N, Bregman N, Shiner T, Mirelman A.
Clin Neurophysiol. 2020 Oct;131(10):2357-2366
https://doi.org/10.1016/j.clinph.2020.06.029 - Dopamine and performance in a reinforcement learning task: evidence from Parkinson's disease. Shiner T, Seymour B, Wunderlich K, Hill C, Bhatia KP, Dayan P, Dolan RJ. Brain. 2012 Jun;135(Pt 6):1871-83. doi: 10.1093/brain/aws083. https://academic.oup.com/brain/article/135/6/1871/329665
- High Frequency of GBA Gene Mutations in Dementia With Lewy Bodies Among Ashkenazi Jews. Shiner T, Mirelman A, Gana Weisz M, Bar-Shira A, Ash E, Cialic R, Nevler N, Gurevich T, Bregman N, Orr-Urtreger A, Giladi N. JAMA Neurol. 2016 Dec 1;73(12):1448-1453.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2565827 - Share Distinguishing Dementia With Lewy Bodies From Alzheimer Disease: What is the Influence of the GBA Genotype in Ashkenazi Jews? Bregman N, Kavé G, Mirelman A, Thaler A, Gana Weisz M, Bar-Shira A, Orr-Urtreger A, Giladi N, Shiner T. Alzheimer Dis Assoc Disord. 2019 Jul-Sep;33(3):279-281.
https://journals.lww.com/alzheimerjournal/Abstract/2019/07000/Distinguishing_Dementia_With_Lewy_Bodies_From.16.aspx
