Dr. Tali Ilovitsh
We develop noninvasive medical ultrasound technologies for diagnostics, monitoring, and therapy for clinically relevant problems. Our research is highly multidisciplinary, combining engineering, physics, biology, chemistry and medicine. We utilize the unique ability of sound waves to penetrate deep into the body, in some cases even through an intact skull, and couple it with gas-bubbles. These bubbles are efficient theranostic probes that can be used for simultaneous imaging and controlled therapy at a targeted site. We develop enhanced ultrasound-mediated gene delivery methods, noninvasive ultrasound surgery, and safe and precise blood brain barrier opening for brain therapy. In parallel, we are developing optically-inspired ultrasonic techniques for overcoming current limitations in ultrasound imaging. Current interests include 3D ultrasound, super-resolution, image processing and machine learning.
Brain Disorders Research
Clinical Neuroscience
Imaging Research
- T. Ilovitsh, E.S Ingham, H. Zhang, A. Ilovitsh, Y. Feng, J. Foiret, A. Kheirolomoom, S.K Tumbale, B.Z Fite, B. Wu, M. Chavez, G. Pelled, D. Gazit, O. Vermesh, I. Steinberg, S.S Gambhir and K.W Ferrara. “Low frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites”. Proceedings of the National Academy of Sciences 117, 12674-12685 (2020). https://www.pnas.org/content/117/23/12674
- T. Ilovitsh, A. Ilovitsh, J. Foiret, C.F. Caskey, J. Kusunose, B.Z. Fite, H. Zhang, L.M. Mahakian, S. Tam, K. Butts-Pauly, S. Qin, and K.W. Ferrara, “Enhanced microbubble contrast agent oscillation following 250 kHz insonation”. Scientific Reports, 8, 1-15 (2018). https://www.nature.com/articles/s41598-018-34494-5
- A. Ilovitsh, T. Ilovitsh, J. Foiret, D.N. Stephens and K.W. Ferrara, “Synthetic axial multi-focal imaging using a single acoustical transmission”. Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 66, 273-284 (2018). https://ieeexplore.ieee.org/abstract/document/8561216?casa_token=LaIWHudPdmkAAAAA:bZImNEcK_Ko-Icw4sx4VWxkILL5U11YR9eYiSuctjkitO2kXnowIZQYn1sE3tMSBVY-MDe2Ypw
- T. Ilovitsh, A. Ilovitsh, J. Foiret and K.W. Ferrara, “Imaging beyond ultrasonically-impenetrable objects”. Scientific Reports, 8, 575901-575911 (2018). https://www.nature.com/articles/s41598-018-23776-7
- T. Ilovitsh, A. Ilovitsh, J. Foiret, B.Z. Fite and K.W. Ferrara, “Acoustical structured illumination for super-resolution ultrasound imaging”. Communications Biology, 1, 1-11 (2018). https://www.nature.com/articles/s42003-017-0003-5
