Dr. Merav Cohen
The Cohen's focuses on exploring cellular communication between immune cells and tissue resident cells, by using genomic technologies, and specifically single-cell RNA sequencing. We are eager to reveal the consequences of immune-controlled cellular interactions on tissue physiological development and tissue pathologies, specifically cancer. We combine experimental mouse models, advanced genomic technologies and computational analysis, together with study of clinical samples, in order to expand our understanding on developmental pathologies and mechanisms of cancer induction, progression, and immune suppression in the tumor microenvironment and metastatic sites. By assessment of similarities and discrepancies in the interactome molecular signature, between tissue development and cancerous conditions, we strive to reveal novel immunotherapy targets.
Cellular & Molecular Neuroscience
Neurodevelopment and Neurogenetic Research
- Merav Cohen, Amir Giladi, Oren Barboy, Pauline Hamon, Baoguo Li, Mor Zada, Anna Gurevich-Shapiro, Cristian Gabriel Beccaria, Eyal David, Barbara B Maier, Mark Buckup, Iris Kamer, Aleksandra Deczkowska, Jessica Le Berichel, Jair Bar, Matteo Iannacone, Amos Tanay, Miriam Merad, Ido Amit. The interaction of CD4 helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response. Nature Cancer. https://www.nature.com/articles/s43018-022-00338-5
- Merav Cohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit. Lung single cell signaling interaction map reveals basophil role in macrophage imprinting. Cell. https://www.sciencedirect.com/science/article/pii/S0092867418311814
- Amir Giladi*, Merav Cohen*, Chiara Medaglia, Yeal Baran, Baoguo Li, Mor Zada, Pierre Bost, Ronnie Blecher-Gonen, Tomer-Meir Salame, Johannes U. Mayer, Eyal David, Franca Ronchese, Amos Tanay and Ido Amit. Dissecting cellular crosstalk by sequencing physically interacting cells. Nature Biotechnology.
https://www.nature.com/articles/s41587-020-0442-2 - Cohen M, Matcovitch O, David E, Barnett-Itzhaki Z, Keren-Shaul H, Blecher-Gonen R, Jaitin DA, Sica A, Amit I, Schwartz M. Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner. EMBO Journal. https://www.embopress.org/doi/full/10.15252/embj.201489293
- Cohen M, Ben-Yehuda H, Gordon S, Schwartz M. Up-regulation of CD200L by Blood-Brain Barrier endothelial cells controls myeloid cell phenotype. Journal of Neuroscience. https://www.jneurosci.org/content/37/4/972?utm_source=TrendMD&utm_medium=cpc&utm_campaign=JNeurosci_TrendMD_0
