Prof. Karen B. Avraham

Prof. Karen B. Avraham

Neurodevelopment and Neurogenetic Research

Research work

Genetic diseases impact a significant portion of the population. We study both sensorineural hearing loss, developmental delay and epilepsy, all of which have a genetic component. Our overall goal is to determine the molecular basis for these diseases, understand the mechanisms and develop therapies. We use genome editing to create models for deafness and epileptic encephalopathy

Gene therapy is being conducted on these models. Regulatory mechanisms are being discovered at the level of non-coding RNA and methylation. Our work has demonstrated that genomic sequencing using high-throughput technologies is effective for genetic diagnoses in a diverse population, providing a guideline for precision medicine

Areas of interest & scientific knowledge

Neurodevelopment and Neurogenetic Research

  • Genetics

Cellular & Molecular Neuroscience

  • Animal Studies
  • Bioinformatics
  • Cell biology
  • Genetics

Brain Disorders Research

  • Animal Studies
  • Epilepsy
  • Human Studies
  • Neurodevelopmental disorders

Behavioral Neuroscience

  • Auditory domain
  • Human Studies
  • Neurodevelopmental disorders
Selected Publications
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