Prof. Dinorah Friedmann-Morvinski
Research topic: Understanding the mechanisms of cancer cell reprogramming and the contributions of the tumor microenvironment.
Research methods: We use an integrative approach to study brain tumor (glioma)-specific neurobiology and oncobiology. Our lab combines cell biology, molecular biology, biochemistry, immunology, cancer research, as well as advanced genome-wide techniques and microscopy. To recapitulate human brain tumors in a mouse model, we use inducible-lentiviral vectors to introduce oncogenes/tumor suppressor genes in a cell-type and tissue specific manner.
Projects in the lab include: Examining the parallel changes in oncogenesis and the induction of pluripotency.
Elucidating the mechanisms involved in cancer cell plasticity.
Identifying the molecular events involved in gliomagenesis.
Designing novel therapeutic approaches to glioblastoma, combining adoptive immune gene therapy and nanotechnology.
Brain Disorders Research
- Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice. Dinorah Friedmann-Morvinski , Eric A Bushong, Eugene Ke, Yasushi Soda, Tomotoshi Marumoto, Oded Singer, Mark H Ellisman, Inder M Verma. Science . 2012 Nov 23;338(6110):1080-4
- Targeting NF-κB in Glioblastoma: A Therapeutic Approach. Dinorah Friedmann-Morvinski , Rajesh Narasimamurthy , Yifeng Xia , Chad Myskiw , Yasushi Soda , Inder M Verma. Sci Adv . 2016 Jan 8;2(1):e1501292.
- Peptide-guided Nanoparticles for Glioblastoma Targeting. Pille Säälik , Prakash Lingasamy , Kadri Toome , Ignacio Mastandrea , Liat Rousso-Noori , Allan Tobi , Lorena Simón-Gracia , Hedi Hunt , Päärn Paiste , Venkata Ramana Kotamraju , Gabriele Bergers , Toomas Asser , Tõnu Rätsep , Erkki Ruoslahti , Rolf Bjerkvig , Dinorah Friedmann-Morvinski *, Tambet Teesalu*. J Control Release 2019 Aug 28;308:109-118
