Prof. David Gurwitz
Research work
Research topic: Pharmacogenomics and biomarkers for CNS disorders.
Research methods: Phenotyping for drug sensitivity in immortalized human lymphoblastoid cell lines, microarray profiling, RNA sequencing, gene and miRNA transfections.
Projects in the lab include:
Biomarkers for precision medicine treatment choice for CNS disorders, including:
- Autism Spectrum Disorder (ASD)
- Bipolar Disorder (BD)
- Major Depressive Disorder
- Anxiety disorders
Areas of interest & scientific knowledge
Brain Disorders Research
Cellular & Molecular Neuroscience
Specialization
Selected Publications
- JVoinsky I, Bennuri SC, Svigals J, Frye RE, Rose S, Gurwitz D. Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin Receptor Expression Positively Correlates with Social and Behavioral Function in Children with Autism. Sci Rep. 2019 Sep 17;9(1):13443. doi: 10.1038/s41598-019-49617-9. http://dx.doi.org/10.1038/s41598-019-49617-9
- Voinsky I, McCarthy MJ, Shekhtman T, Kelsoe JR, Gurwitz D.SCN11A mRNA levels in female bipolar disorder PBMCs as tentative biomarker for distinct patient sub-phenotypes. Drug Dev Res. 2019 Dec;80(8):1128-1135. doi: 10.1002/ddr.21598. https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.21598
- Just KS, Turner RM, Dolžan V, Cecchin E, Swen JJ, Gurwitz D, Stingl JC. Educating the Next Generation of Pharmacogenomics Experts: Global Educational Needs and Concepts. Clin Pharmacol Ther. 2019 Aug;106(2):313-316. doi: 10.1002/cpt.1471. https://doi.org/10.1002/cpt.1471
- Hadar A, Milanesi E, Walczak M, Puzianowska-Kuźnicka M, Kuźnicki J, Squassina A, Niola P, Chillotti C, Attems J, Gozes I, Gurwitz D. SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. Sci Rep. 2018 May 31;8(1):8465. doi: 10.1038/s41598-018-26547-6.
https://www.nature.com/articles/s41598-018-26547-6 - Milanesi E, Voinsky I, Hadar A, Srouji A, Maj C, Shekhtman T, Gershovits M, Gilad S, Chillotti C, Squassina A, Potash JB, Schulze TG, Goes FS, Zandi P, Kelsoe JR, Gurwitz D. RNA sequencing of bipolar disorder lymphoblastoid cell lines implicates the neurotrophic factor HRP-3 in lithium's clinical efficacy. World J Biol Psychiatry. 2019 Jul;20(6):449-461. doi: 10.1080/15622975.2017.1372629. https://www.tandfonline.com/doi/full/10.1080/15622975.2017.1372629
