

Dr. Assaf Ramot
The Ramot Lab studies how the brain transforms intention into action by examining the neural circuits that support motor learning, exploration, and adaptive behavior. We focus on how internal states—particularly acute and chronic stress—reshape cortical circuit dynamics and influence learning and performance. Using advanced behavioral paradigms in rodents combined with state-of-the-art optical imaging and neural manipulation, we track and perturb the activity of identified neuronal populations across learning and experience. Our work integrates systems neuroscience, circuit analysis, and computational approaches to uncover general principles governing plasticity, resilience, and vulnerability. By linking brain dynamics to behavior across timescales, our goal is to understand how complex skills emerge, stabilize, and adapt under changing internal and environmental conditions.
Behavioral Neuroscience
Imaging Research
System & Physiological Neuroscience
- Ramot, A., Taschbach, F. H., Yang, C. Y., Hu, Y., Chen, Q., Morales, B., Wang, C. W., Wu, A., Tye, K. M., Benna, M. & Komiyama T. (2025). Motor learning refines thalamic influence on motor cortex. Nature. 1–10. https://doi.org/10.1038/s41586-025-08962-8
- Ramot, A., Jiang, Z., Tian, J.B., Nahum, T., Kuperman, Y., Justice, N., & Chen, A.* (2017). Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress. Nature Neuroscience, 20(3), 385–388.
- Ezra-Nevo, G., Prestori, F., Locatelli, F., Soda, T., Brinke, M.M. ten, Engel, M., Boele, H.-J., Botta, L., Leshkowitz, D., Ramot, A., et al. (2018). Cerebellar learning properties are modulated by the CRF receptor in granular cells. Journal of Neuroscience, 3106–3115.
- Ezra-Nevo, G., Volk, N., Ramot, A., Kühne, C., Tsoory, M., Deussing, J.M., Chen, A.* (2018) Inferior olive CRF plays a role in motor performance under challenging conditions. Translational Psychiatry, 8:107.
- Kuperman, Y., Weiss, M., Dine, J., Staikin, K., Golani, O., Ramot, A., Harmelin, A., Deussing M.J., Eder, M., & Chen, A.* (2016). CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting. Cell Metabolism, 23(6), 1185–1199.
