Dr. Angela Ruban
Research work
Main projects in the lab include:
1. Blood glutamate scavenging as a novel neuroprotective treatment in the neurotrauma.
2. Role of blood liver enzyme and glutamate in the pathophysiology of metastatic brain tumors.
3. ADHD pathophysiology and stimulants mood of action: MRS clinical study
Research methods: In-vivo MRI, MRS, HPLC, intracranial mouse tumor models, brain metastatic animal models, immunohistochemistry, biochemistry, spinal cord injury animal models, in-vitro cell cultures, qPCR, molecular biology, drug sustained-release delivery: nano-drop formulation.
Areas of interest & scientific knowledge
Brain Disorders Research
Cellular & Molecular Neuroscience
Clinical Neuroscience
Specialization
Selected Publications
- Ruban, A, Biton, I, Markovich, A. and Mirelman, D.: MRS of Brain Metabolite Levels Demonstrates the Ability of Scavenging of Excess Brain Glutamate to Protect against Nerve Agent Induced Seizures. Int. J. Mol. Sci. Vol. 16 (2); pp. 3226-36, 2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346891
- Ruban, A, Cohen-Kashi Malina K, Cooper I, Graubardt N, Babakin L, Jona G, and Teichberg V. Combined treatment of an ALS rat model with recombinant GOT1 and Oxaloacetic acid: a novel neuroprotective treatment. Neurodegen Dis. 2015. https://www.karger.com/Article/FullText/382034
- Goldshmit Y, Jona G, Schmukler E, Solomon S, Pinkas-Kramarski R, Ruban A. Blood Glutamate Scavenger as a Novel Neuroprotective Treatment in Spinal Cord Injury. J Neurotrauma, May 15, 2018. https://www.liebertpub.com/doi/full/10.1089/neu.2017.5524
- Goldshmit Y, Banyas E, Bens N, Yakovchuk A, Ruban A. Blood glutamate scavengers and exercises as an effective neuroprotective treatment in mice with spinal cord injury. J Neurosur:spine, June 2020. https://doi.org/10.3171/2020.4.SPINE20302
- Ruban, A, Mohar, B, Jona, G, Teichberg, VI.: Blood glutamate scavenging as a novel neuroprotective treatment for paraoxon intoxication. J Cereb Blood Flow Metab. Vol. 34(2); pp. 1-7, 2014.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915200
