Prof. Ronit Satchi-Fainaro
Combining multidisciplinary basic, translational and clinical approaches for cancer therapy
In our lab, we invest multidisciplinary efforts to elucidate the basic molecular mechanisms responsible for cancer progression to an aggressive, metastatic, drug-resistant phenotype in order to reveal new “druggable targets” for clinical translation. To achieve this goal, we exploit a rich platform of cell lines, ex vivo 3D models and in vivo mouse models of cancer as well as fresh and archived tissue specimens obtained from fruitful collaborations with several of TAU’s affiliated hospitals. We use a range of molecular and functional techniques to identify and validate new markers and drivers of cancer progression. The newly-gained knowledge is harnessed for the design of novel clinically-relevant polymer-based diagnostic and therapeutic tools for cancer. Our vision is that our multidisciplinary approach will revolutionize our perception of tumor progression and consequently the way we diagnose and treat cancer.
Brain Disorders Research
Cellular & Molecular Neuroscience
Imaging Research
- Yeini E, Ofek P, Albeck N, Rodriguez Ajamil D, Neufeld L, Eldar-Boock A, Kleiner R, Vaskovich D, Koshrovski-Michael D, Israeli Dangoor S, Krivitsky A, Burgos Luna C, Shenbach-Koltin G, Goldenfeld M, Hadad O, Tiram G, Satchi-Fainaro R. Targeting Glioblastoma: Advances in Drug Delivery and Novel Therapeutic Approaches. Advanced Therapeutics, 2020, 2000124.
- Conniot J, Scomparin A, Peres C, Yeini E, Pozzi S, Matos AI, Kleiner R, Moura LIF, Zupančič E, Viana AS, Doron H, Gois PMP, Erez N, Jung S, Satchi-Fainaro R, Florindo HF. Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators. Nat Nanotechnol. 2019 Sep;14(9):891-901.
- Ferber S*, Tiram G*, Sousa-Herves A, Eldar-Boock A, Krivitsky A, Scomparin A, Yeini E, Ofek P, Ben-Shushan D, Vossen LI, Licha K, Grossman R, Ram Z, Henkin J4, Ruppin E, Auslander N, Haag R, Calderón M, Satchi-Fainaro R. Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome. Elife (2017) Oct 4;6. pii: e25281.
- Blau R, Epshtein Y, Tiram G, Pisarevsky E, Israeli S, Yeini E, Krivitsky A, Eldar-Boock A, Ben-Shushan D, Green O, Ben-Nun Y, Merquiol E, Schwartz H, Blum G, Erez N, Grossman R, Ram Z, Shabat D, Satchi-Fainaro R, Image-Guided Surgery Using Near-Infrared Turn-ON Fluorescent Nanoprobes for Precise Detection of Tumor Margins, Theranostics, 2018 Jun (13): 3437-3460
- Tiram G*, Ferber S*, Ofek P, Eldar-Boock A, Ben-Shushan D, Yeini E, Krivitsky A, Blatt R, Almog N, Henkin J, Amsalem O, Yavin E, Cohen G, Lazarovici P, Lee JS, Ruppin E, Milyavsky M, Grossman R, Ram Z, Calderón M, Haag R, Satchi-Fainaro R. Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma. FASEB J. 2018 32:5835-5850.
