Prof. David Gurwitz
Research work
Research topic: Pharmacogenomics and biomarkers for CNS disorders.
Research methods: Phenotyping for drug sensitivity in immortalized human lymphoblastoid cell lines, microarray profiling, RNA sequencing, gene and miRNA transfections.
Projects in the lab include:
Biomarkers for precision medicine treatment choice for CNS disorders, including:
- Autism Spectrum Disorder (ASD)
- Bipolar Disorder (BD)
- Major Depressive Disorder
- Anxiety disorders
Areas of interest & scientific knowledge
Brain Disorders Research
Cellular & Molecular Neuroscience
Specialization
Selected Publications
- Voinsky I, Goldenberg-Bogner O, Israel-Elgali I, Volkov H, Puzianowska-Kuźnicka M, Shomron N, Gurwitz D. RNA sequencing comparing centenarian and middle-aged women lymphoblastoid cell lines identifies age-related dysregulated expression of genes encoding selenoproteins, heat shock proteins, CD99, and BID. Drug Dev Res. 2024 Nov;85(7):e70011. doi: 10.1002/ddr.70011. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/ddr.70011
- Voinsky I, Zoabi Y, Shomron N, Harel M, Cassuto H, Tam J, Rose S, Scheck AC, Karim MA, Frye RE, Aran A, Gurwitz D. Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder. Int J Mol Sci. 2022 Aug 30;23(17):9843. doi: 10.3390/ijms23179843.
https://www.mdpi.com/1422-0067/23/17/9843 - Israel-Elgali I, Hertzberg L, Shapira G, Segev A, Krieger I, Nitzan U, Bloch Y, Pillar N, Mayer O, Weizman A, Gurwitz D, Shomron N. Blood transcriptional response to treatment-resistant depression during electroconvulsive therapy. J Psychiatr Res. 2021 Sep;141:92-103. doi: 10.1016/j.jpsychires.2021.06.039.
https://www.sciencedirect.com/science/article/pii/S0022395621004131 - Shapira G, Shomron N, Gurwitz D. Ethnic differences in alpha-1 antitrypsin deficiency allele frequencies may partially explain national differences in COVID-19 fatality rates. FASEB J. 2020 Nov;34(11):14160-14165. doi: 10.1096/fj.202002097. https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.202002097
- JVoinsky I, Bennuri SC, Svigals J, Frye RE, Rose S, Gurwitz D. Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin Receptor Expression Positively Correlates with Social and Behavioral Function in Children with Autism. Sci Rep. 2019 Sep 17;9(1):13443. doi: 10.1038/s41598-019-49617-9. http://dx.doi.org/10.1038/s41598-019-49617-9
- Hadar A, Milanesi E, Walczak M, Puzianowska-Kuźnicka M, Kuźnicki J, Squassina A, Niola P, Chillotti C, Attems J, Gozes I, Gurwitz D. SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. Sci Rep. 2018 May 31;8(1):8465. doi: 10.1038/s41598-018-26547-6.
https://www.nature.com/articles/s41598-018-26547-6 - Milanesi E, Voinsky I, Hadar A, Srouji A, Maj C, Shekhtman T, Gershovits M, Gilad S, Chillotti C, Squassina A, Potash JB, Schulze TG, Goes FS, Zandi P, Kelsoe JR, Gurwitz D. RNA sequencing of bipolar disorder lymphoblastoid cell lines implicates the neurotrophic factor HRP-3 in lithium's clinical efficacy. World J Biol Psychiatry. 2019 Jul;20(6):449-461. doi: 10.1080/15622975.2017.1372629. https://www.tandfonline.com/doi/full/10.1080/15622975.2017.1372629
