Prof. David Sprinzak
Research work
Eesearch in the lab focuses on elucidating design principles of developmental patterning processes regulated by juxtacrine signaling such as the Notch signaling pathway. We combine mathematical modeling and quantitative imaging to understand how the interplay between Notch signaling and cellular and tissue morphology affects developmental patterning. In recent years we have focused on elucidating the mechanisms underlying the patterning of hair cells in the inner ear.
Areas of interest & scientific knowledge
Cellular & Molecular Neuroscience
Imaging Research
Selected Publications
- O. Shaya*, U. Binshtok*, M. Hersch, D. Rivkin, S. Weinreb, L. Amir-Zilberstein, B. Khamaisi, O. Oppenheim, R. A. Desai, R. Goodyear, G. Richardson, C. S. Chen, and D. Sprinzak. Cell-cell contact area affects Notch Signaling and Notch dependent patterning. (2017) Developmental Cell 40(5):505-511.e6.
- O. Loza, I. Heemskerk, N. Gordon-Bar, L. Amir-Zilberstein, Y. Jung, and D. Sprinzak. A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes. (2017) eLife ;6:e24820.
- Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Joseph Salomone, Ian Campbell, FearGod V. Okwubido-Williams, Matthew R. Hass, Natanel Eafergan, Kenneth H. Moberg, Rhett A. Kovall, Raphael Kopan*, David Sprinzak*, Brian Gebelein*. Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism (2020). Elife. 2020 Apr 16;9. doi: 10.7554/eLife.53659 (* co-corresponding authors).
- Roie Cohen, Liat Amir-Zilberstein, Micha Hersch, Shiran Woland, Shahar Taiber, Fumio Matsuzaki, Sven Bergmann, Karen B. Avraham, David Sprinzak. Shear forces drive precise patterning of hair cells in the mammalian inner ear. (2019) bioRxiv 707422; doi: https://doi.org/10.1101/707422.
