Prof. Ben Maoz
Research work
As standard tools fail to mimic the human brain physiology, new tools are required for better understanding neuronal disease and for more efficient drug development. Our lab develops state-of-the art in vitro models, in a concept known as "Organ-on-a-Chip", which is mimicking the organ functionality in a micro fluidic chip. We are using these tools to study brain physiology in health and disease.
Areas of interest & scientific knowledge
Neurodevelopment and Neurogenetic Research
Cellular & Molecular Neuroscience
Selected Publications
- Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities B. M. Maoz, A. Herland, O. Y. F. Henry, W. D. Leineweber, M. Yadid, J. Doyle, R. Mannix, V. J. Kujala, E. A. FitzGerald, K. Kit Parker and D. E. Ingber, 2017
- Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips A. Herland, B. M. Maoz, D. Das, M. R. Somayaji, R. Prantil-Baun, R. Novak, M. Cronce, T. Huffstater, S. S. F. Jeanty, M. Ingram, A. Chalkiadaki, D. B. Chou, S. Marquez, A.Delahanty, Sasan Jalili-Firoozinezhad, Y. Milton, A. Sontheimer-Phelps, B. Swenor, O. Levy, K. K. Parker, A. Przekwas & D. E. Ingber, 2020
- Robotic fluidic coupling and interrogation of multiple vascularized organ chips R. Novak, M. Ingram, S. Marquez, D. Das, A. Delahanty, A. Herland, B. M. Maoz, S.S. F. Jeanty, M.h R. Somayaji, M. Burt, E.h Calamari, A. Chalkiadaki, A. Cho, Y. Choe, D. B. Chou, M. Cronce, S. Dauth, T. Divic, J. F-Alcon, T. Ferrante, J. Ferrier, E. A. FitzGerald, R. Fleming, S. J.-Firoozinezhad, T. Grevesse, J. A. Goss, T. H.-Indik, O. Henry, C. Hinojosa, T. Huffstater, K.-J. Jang, V. Kujala, L. Leng, R. Mannix, Y. Milton1, J. Nawroth, B. A. Nestor, C. F. Ng, B. O’Connor, T.-E Park, H. Sanchez1, J. Sliz, A. S.-Phelps, B. Swenor, G. Thompson II, G. J. Touloumes, Z. Tranchemontagne, N. Wen, M. Yadid, A. Bahinski, G. A. Hamilton, D. Levner, O. Levy, A. Przekwas, R. Prantil-Baun, K. K. Parker and D. E. Ingber, 2020
- Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip B. M. Maoz S, t. Dauth, S. P. Sheehy, M. A. Hemphill, T. Murty, M. K. Macedonia, A. M. Greer, Bo Budnik and K. K. Parker, 2017
- A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells B. M Maoz, A. Herland, E. A FitzGerald, T. Grevesse, C. Vidoudez, A. R Pacheco, S. P Sheehy, T.-E. Park, S. Dauth, R. Mannix, N. Budnik, K. Shores, A. Cho, J. C Nawroth, D. Segrè, D. E Ingber, 2018, Kevin Kit Parker
